Categorization of chemicals based on similar structure activity and application of read-across, along with use of existing test data, were the most effective means of reducing animal testing.
In 2004, the U.S. Department of Energy DOEE) conducted an initial screening and categorization of renewable chemicals that could be co-produced as side streams of biofuels and bioenergy [ 5].
The accuracy of this aggregate activity can be demonstrated by the correct categorization of most replicate chemicals into the same NRG (see Table 1)., despite differences in NR assay profiles.
The process involves conducting the assessment by life stages (i.e., in utero, postnatal, peripubertal), adopting a general categorization of the environmental chemicals by biologic persistence, and collecting and storing biologic specimens that are most likely to yield meaningful information.
Some of categorization schemes, such as that used in Registration, Evaluation, Authorization and Restriction of Chemicals (REACH) [5], make use of criteria that are followed by a weight-of-evidence analysis; while others, such as those for categorization of plant protection products (PPPs), base management decisions on basic PBT criteria only.
It follows that TMFs measured in the environment are a suitable tool for the evaluation of chemicals which have been in use for some time, but are less useful for the PBT categorization of new chemical substances under REACH or new PPPs under EU Regulation 1107/2009 [1107/2009
Rapid diagnosis of chemicals.
Proper Storage of Chemicals.
Proper Disposal of Chemicals.
Indeed, chemical categories with a majority of chemicals providing extreme pH values have been finally accepted to be the validated applicability domain of the Corrositex assay, and it is therefore now instrumental for hazard sub-categorization of corrosive chemicals and products in the context of UN regulations for transportation of dangerous goods.
