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Categorization of genes on the list based upon Gene Ontology (GO) assignments were also done using the DAVID program and the outcome showed similar categories to those assigned under the KEGG Pathway (not shown).
The systematic categorization of genes by their functions by the Gene Ontology Consortium (GO) has initiated the widespread practice of functional enrichment analysis; many portals have been developed over the years and have led to the continual refinement of gene list analysis algorithms39,40,41.
EASE uses the gene ontology (GO) systems for the categorization of genes.
Functional categorization of genes in the severely attenuated mutants revealed significant enrichment for RNA binding proteins, suggesting the significance of post-transcriptional gene regulation in parasite development and emphasizing its importance as an antimalarial target.
An archetypal result presented in genomic analyses is the categorization of genes into functional categories.
Therefore, we manually updated our previous functional categorization of genes into molecular categories [ 7] and, when possible, subcellular categories.
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The categorization of gene expression is given as follows.
Using DAVID's categorization of gene functions, subsets of genes were identified that may be important within the piRNA pathway.
As an additional resource, bioinformatic analyses have enabled categorization of gene sets in V. dahliae, strain VdLs.17 [ 19].
We feel that a simple categorization of gene expression into two or three categories (like underexpression, average and overexpression) is insufficient to capture the true behavior of genes.
To achieve a multi-level categorization of gene products, we utilized Gene Ontology terms [ 36] in combination with the classification system of FunCat [ 37].
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