The assessment of the regional soil type was difficult to categorise due to frequent changes of pastures in some flocks.
Errors in diagnostic thinking are not easy to assess, as harm that results may be categorised as due to a different source, eg caused by (the wrong) treatment, or a delay to the right one.
The remaining 3 calves could not be categorised, partly due to the lack of certain data.
The identification of viral NA in samples sent for bacterial culture is interesting and probably reflects that clinical symptoms are not easily categorised as due to bacterial or viral infection in the CNS.
When VFs could not be categorised, for instance, due to non-glaucomatous VF changes, or unreliable test performance by software assessment, exams were categorised as 'other' not to confound stratification.
Death was categorised as death due to HNSCC.
The etiology of AKI, categorised as ischaemic, due to sepsis or other (including contrast nephropathy and rabdomyolysis), was assessed by the treating physician.
It must be noted that simply 'Bulldog' was categorised as Utility due to the definition for UK Kennel Club Utility Group, although it is likely that some or all of these may have actually been the 'American Bulldog' rather than the English or British Bulldog as assumed; the American version is anecdotally popular in this area.
We made a post-hoc decision to categorise the discontinuation due to reduction in LVEF as a clinical cardiotoxic event due to the implied harm being greater than for a reduction in LVEF alone (sub-clinical).
