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Four other studies have been categorised as neutral as they are only marginal supportive.
Only TL-118-treated mice showed significant tumour-growth delay, which could be categorised as either partial response (PR) or complete response (CR).
"There are several that I would categorise as entrepreneurial.
Responses were categorised as complete response, partial response, stable disease, or progressive disease.
The initial response as assessed clinically was categorised as complete or partial by the WHO criterion (WHO, 1979).
For the primary efficacy analysis, patients who withdrew before week 28 were categorised as not achieving partial remission.
Tumour response was evaluated using RECIST and categorised as complete (CR), partial (PR), stable disease (SD) or progressive disease (PD).
However, five out of 10 tumours with no response were incorrectly categorised as complete or partial response on the clinical assessment (specificity 50%; CI 19 81%).
Response was categorised as complete response, partial response, static disease or progressive disease; the minimum criterion for response was disease that did not progress for at least 6 months.
Different assessment tools are used to measure changes in disease activity for the different autoimmune diseases; therefore, to enable an approximate comparison across the diseases, clinical response was categorised as complete response, partial response and no response, as judged at the discretion of the investigators.
Tumour responses were categorised as a complete or partial response, or progressive disease or s.d.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com