For that reason, pulmonary physicians speak of occupational asthma (OA), a category that includes both sensitization and irritation (Bernstein et al., 2006b; Francis et al., 2007; Malo and Newman-Taylor, 2007; Tarlo et al., 2008); studies of OA do not often distinguish between hypersensitivity and irritant causes (Nicholson et al., 2005).
Mann Whitney Analysis of "Sensitization Scores" between different categories of asthmatic patients.
However, electrophilicity alone cannot be used to directly compare sensitization potential across mechanistic categories and subdomains (e.g., Michael acceptors versus acylators versus SnAr) (Enoch et al., 2009, 2010).
This conclusion is supported by the observation that the rates of chronic beryllium disease (CBD) and sensitization were constant across all the categories of exposure used by Rosenman et al. (2005).
Within mechanistic domains and sub categories of electrophiles, the ability of compounds to cause respiratory sensitization has been related to their relative elec-trophilicity.
For the sensitization outcome at year five, however, numbers of children in some exposure categories were low and it was therefore necessary to merge the exposed categories to create a single category 'exposed at any age up to year 5'.
Similar cost categories and methodological costing approaches were used for both interventions covering district costs associated with community sensitization, behaviour change and communication, drug distribution and administration, training and supervision.
In terms of cost category, personnel costs amounted to US$6,693 (46% of the total cost), mainly for training (US$4,285) and sensitization (US$1,549).
One possibility is that early exposure causes the immune system to produce protective antibodies, but without allergic sensitization.
The study, which was published in the journal Neurology, involved a phenomenon called central sensitization, which Dr. Schmelz said had been examined mostly in terms of pain.
