When the F.D.A. approved Pradaxa in October 2010, the drug was hailed as the first in a new category of replacements for warfarin, the nearly 60-year-old drug used to prevent strokes in people with a heart-rhythm disorder known as atrial fibrillation.
One of the more common is shown here; reactions in this category consist of replacement of a group designated Y (often a hydrogen atom) in an aromatic molecule by an electrophilic agent designated E. Both substituents can be any one of various groups (e.g., hydrogen atoms or nitro, bromo, or tert-alkyl groups).
We conducted separate analyses for subgroups defined according to admitting department, use of mechanical ventilation, type of surgery, diagnostic category, renal replacement therapy, use of selective vs. non-selective beta-blockers, and new vs. long-term beta-blocker use.
The calculations of the number of replacement and addition batteries for each category listed in Table 7 can be found in Ebaid et al. (2013).
This replaced the theory of simple types which he developed in 1921, about which he wrote, "[E]ven as I as I was constructing my theory of types, I considered it to be only an inadequate stop-gap In 1922 I outlined a concept of semantical categories as a replacement for the hierarchy of types, which is quite unintuitive to me" (Collected Works, 421).
Next year EPA will issue a second set of SNAP rules to hasten HFC replacement in more categories of equipment.
In the spatial domain, this type of techniques can be broadly classified into two categories: LSB replacement and LSB matching.
Applying the net condition categories, 'good', 'serviceable' and 'needs replacement', 33 and 30percentt of the nets in communities near water for washing were in need of replacement versus 16 and 22percentt in the communities that were farther away from water.
The previously mentioned data are derived from the reports of different National Services responsible for the post-earthquake crisis management regarding the repair/strengthening or replacement costs or other categories of costs for the rehabilitation of earthquake victims (demolitions, rehabilitations).
For example, seven competitive funding programs would give preference points to applications with evidence meeting one of those categories, and a replacement for School Improvement Grants requires local educational agencies to include "evidence-based interventions" in their comprehensive support and improvement plans.
