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Three classification schemes were tested: Exposed against Buried (EX, 2 categories), Extended, Helix and Other (EHO, 3 categories) and a combination of the two previous schemes (EX_EHO, 6 categories).
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Figure 3 shows the way these four context categories extend each other for better context integration and service adaptation.
As more real-world brands in more categories extend into the virtual marketplace, branding will increasingly seem like the norm, pushing unbranded virtual items down in status to the level of store brands and generics.
As such, this tripartite model builds on established diagnostic categories, extending them to sub-threshold presentations via the use of a clinical staging framework, and further refining them by classifying cases on the basis of a putative clinical phenotype linked to a proposed underlying pathophysiology and illness trajectory.
The atom category extended fingerprint 3DXfp showed higher performance than 3DAPfp for recovery of ROCS Color Tanimoto analogs, in line with the fact that ROCS Color primarily encodes pharmacophores.
We recently showed that large databases can be formatted for very fast searching with various 2D-fingerprints using the city-block distance as similarity measure, in particular a 2D-atom pair fingerprint (APfp) and the related category extended atom pair fingerprint (Xfp) which efficiently encode molecular shape and pharmacophores, but do not perceive stereochemistry.
These fingerprints describe constitution and topology (42D molecular quantum numbers, MQN), structural features (34D SMILES fingerprint SMIfp), molecular shape (20D atom pair fingerprint APfp), pharmacophores (55D atom category extended atom pair fingerprint Xfp) and substructures (1024D binary substructure fingerprint Sfp) (Table 1).
Dr Dan Mercea, lecturer in the department of sociology at City University, says that for several years there has been a move away from party politics towards the protest activities that academics refer to as "contentious politics", a broad category extending from strikes and demonstrations to violence and riots.
What's more, this category extends to frontier-tech companies such as GGV investment Niu, maker of an electric scooter popular among urban Chinese millennials who use them not just to navigate the clogged streets of Beijing, but also to get away from the smog and stress.
Those annotations are appended in mmCIF categories (possibly extended) such as struct_site, struct_site_gen and struct_ref, or in a new category specific to PDBMLplus such as gene_ontology.
The assignments of genes to the original GO categories were extended to include parental terms (that is, a gene assigned to a given category was automatically assigned to all the parent categories as well).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com