Intravenous opioid, however, has catastrophic side effects like respiratory depression [8].
Any geoengineering scheme powerful enough to eliminate tornadoes would also by definition have catastrophic side effects.
Also, as the thalidomide mess reminded us many years ago, supposedly beneficial medicines can cause catastrophic side effects that may not be recognized until extensive controlled clinical experience has been gained.
Despite such catastrophic side effects, the FDA decided to leave the risk-benefit decision on Xiaflex up to a patient and his doctor.
Would the spleen be able to cope with removing millions of IEs, or could it lead to potentially catastrophic side effects such as splenic rupture?
Marr, who mostly slept through his brushes with death, was oblivious to the dramas of his bedside and the potentially "catastrophic side-effects" of his post-stroke treatment.
Hell and Heaven exist - characters can see them, sometimes - and angels visit the earth with bursts of Holy Presence and catastrophic side-effects.
Steel (2008), building on the work of others (Schlosser and Wagner 2004), therefore attempts to reconstruct this argument as a way of showing that evolved systems are more likely to be modular: systems made of independently manipulable parts can quarantine the effects of changes to specific parts, giving them added flexibility to make local changes without causing catastrophic side-effects.
Primate work may provide further reassurance that there are no catastrophic unwanted side effects of the treatment (Tachibana et al., 2009), but short-term experiments will not detect late-onset complications related to epigenetic reprogramming.
The storm was catastrophic; perhaps the only positive side effect is that it changed the calculus for the investors holding the island's bonds.
These non-invasive approaches are especially promising for current MB treatments that damage the still-developing brain and result in catastrophic life-long side effects [ 31].
