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It is what can be described as the catastrophe effect.
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Arrow indicates catastrophe event.
It was the biggest marine oil spill in history – an environmental catastrophe with effects that will be felt for many years.
When the Exxon Valdez ran aground in Alaska's Prince William Sound, it unleashed a regional catastrophe whose effects continue to play out these two decades later.
Within the framework of the model of the extended protective structural cap, this provides a direct explanation for the catastrophe-promoting effect of EBs in vitro.
At physiological concentrations, which have been estimated to be in the range of several 10s of nM (Katsuki et al., 2009; Tirnauer et al., 2002), EBs have a catastrophe-stimulating effect in vitro (Bieling et al., 2007; Komarova et al., 2009).
These abnormal mitotic events lead to mitotic catastrophe, a desirable effect of a cancer therapeutic drug.
The motive may have been to avoid the risk of natural disasters and nuclear catastrophes, but the effect has been to take on more risk.
Thus, many households in LMICs lack adequate financial protection; households face financial catastrophe and impoverishing effects of paying for health services out-of-pocket [ 6].
We generally deal effectively with cause-and-effect catastrophes that have the "advantage" of immediacy.
One of us once declared that a workable definition of a public health catastrophe was a health effect so powerful even an epidemiological study could detect it.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com