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Lastly, the arrangement of the catalytically engaged HECT domain restricts the flexibility of the active site relative to the portion of the E3 that associates with the target protein, a feature that enables the enzyme to prioritize the lysine that is modified in vivo.
Similar(59)
Specifically, a catalytically active IRE1 unit engaged in HAC1 or XBP1 mRNA splicing is generated within the IRE1 oligomer, while IRE1 engaged in RIDD resides within an IRE1 monomer/dimer.
In this conformation, the NBDs are engaged but the NBSs have not formed the canonical configuration and are therefore not catalytically competent.
Engaged, not engaged.
Peacefully engaged.
He was engaged.
We are fully engaged.
"Smart, funny, very engaged.
They recently got engaged.
We got engaged.
They got engaged.
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