Sentence examples for catalytic positions from inspiring English sources

Although the catalytic center of an enzyme is usually highly conserved, there have been reports of proteins, like those of the RGC group of ePKs, with substitutions at essential catalytic positions, which convert the enzyme into a catalytically inactive form.

In particular, INTREPID is able to better predict catalytic positions that are not globally conserved and hence, attains improved sensitivity at high values of specificity.

A number of enzyme families exhibit variability in the location of catalytic residues (Todd et al., 2002), while other enzyme families exhibit variation at catalytic positions.

While the scoring functions discussed in the previous section are designed to detect family-defining positions (and catalytic positions in particular), this basic tree traversal protocol can be adapted to detect SDPs as well.

While the vast majority of kinase domains clearly demonstrate the expected presence of this important catalytic position, there are a number of salient exceptions in particular the catalytically active With No Lysine (WNK) kinase, in which the catalytic lysine accomplishes its role using a different subdomain[30], [31].

In order to minimize effects due to a change in the size and structure at a key catalytic position, we chose to substitute the Asp32 residue with the most conservative replacement in terms of molecular volume and polarity, an asparagine.

Heterologous expressions of CsF3′5′H in yeast were carried out to further confirm the catalytic position of CsF3′5′H enzyme in flavonoid pathways.

In the "inhibited" conformation (occupancy ∼70%), Asp336 pulls His339 away from its catalytic position, and Cys129 flips to an inactive rotamer.

Most members of the latter group possess a Lys or Arg residue in the "catalytic" position and hence exhibit "PD-EXK-K" (see above) or "PD-EXR-K" variants of the active site.

Both flavivirus NS5RdRp structures were obtained with a Mg2+ ion in a non-catalytic position near the active center.

Catalytic triad positions were determined as the positions within conserved folds corresponding to the HYE triad from HsPARP1 and AtPARP1.