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Freddie stows aboard and a catalytic engagement ensues between the two men, far beyond their getting high on Freddie's brand of moonshine.
For example, is the increase in Est1/Est2 binding observed in S phase the result of increased association with the telomere (recruitment), or instead an increase in the actual catalytic engagement of the telomerase enzyme (activation)?
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Clearly, the combined effects of leadership training, catalytic investment, political engagement, and evidence-based budgeting are solving the CHPS start-up problem.
Through broad-based stakeholder engagement, catalytic partnerships, and a collective vision, UINCD is working to reframe integrated health service delivery in Uganda.
The TCR has no intrinsic catalytic activity, but TCR engagement results in tyrosine phosphorylation of downstream targets by non-receptor tyrosine kinases.
Similar engagement of catalytic glutamyl 1201 with ATP, Mg2+, and H2O placed at NBD2 was not observed.
To explore the effects of SH2 and SH3 domain engagement on catalytic activity within the context of Lyn, Fyn1, and Fyn2, analogous regulatory state mutants of each SFK were generated.
In the basal state, catalytic activity is constrained by engagement of the SH2 domain by a phosphorylated C-terminal tyrosine 531 [ 13].
In the nonspecific mode, docking of non-SRL substrates permits only partial engagement of the catalytic residues and results in an impaired cleavage rate.
In contrast, docking in the specific mode with the SRL enables full engagement of the catalytic machinery (including Y47 and H49) to achieve a ∼1000-fold ∼1000-foldcement of site-cleavage of the Srateenhancementcleavage of ssNA substrates.
We also show the engagement of the catalytic interface in both the activating interaction of Irga6 with Irgb6 [ 6, 9] and the inhibitory interaction between Irga6 and the GMS subfamily protein, Irgm3 [ 9].
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