Sentence examples for catalytic determinant from inspiring English sources

However, no ATPase activity was observed in the mt-PCPH protein, probably due to a loss of conserved catalytic determinant regions in the truncated form, which may affect its tertiary structure and then the enzymatic function.

To identify the structural determinants for sGC catalytic activity, we determined the X-ray structure of the wild-type heterodimeric αβGC catalytic domains of human sGC in the apo form at 1.9 Å resolution.

Thus, the intact oxazinone ring, and not simply the carbonyl functional group, is a determinant of catalytic activity of CYP2B6 toward EFV.

GAD and GABA-TP catalytic activities were determined in vitro in WT plantlets subjected to NaCl treatments to decipher biochemical determinants of GABA accumulation.

Observed interactions of the products with the dizinc metal center and active-site residues provide insight into the substrate binding determinants and catalytic mechanisms of these enzymes.

In addition, P450s have a tendency to eventually undergo irreversible inactivation that can be promoted by reduced coupling between substrate binding and conformational shifts, as well as by other poorly understood determinants of catalytic stability [ 19, 42, 43].

The parallels between cis-CaaD and Cg10062 coupled with the absence of a robust cis-CaaD activity and isomer specificity in Cg10062 indicate that a fully functional cis-CaaD requires catalytic features and specificity determinants beyond the identified core set.

Transport kinetic analysis revealed that I89M mutant had a 2.7-fold reduction in maximal transport velocity (Vmax) with no significant change in apparent binding affinity (Km) towards the prototype PMAT substrate 1-methyl-4-phenylpyridinium (MPP+), suggesting that I89 is an important determinant for the catalytic activity of PMAT.

The presented presteady-state investigations clearly demonstrated that the reductive half reaction is the main determinant for the catalytic efficiency of AmPDH.

Arg219 is one of the structural determinants of the catalytic specificity of the alanine racemase.

Crystallographic data of two components of L. rubellus lumbrokinase were obtained, revealing the structure determinants of their catalytic mechanisms (Tang et al. 2002 and Wang et al. 2005).