Sentence examples for catalytic architecture from inspiring English sources

The overall findings indicate that in FNR the volume of the residue at position 266 is essential to attain the catalytic architecture between the nicotinamide and isoalloxazine rings at the active site and, therefore, for an efficient HT process.

Data demonstrated that the cold-adapted enzyme exhibits an increased catalytic efficiency at low and moderate temperatures and, more interestingly, a local flexibility in the region that controls the correct folding of the catalytic architecture, as well as a rigidity in the hydrophobic core.

Taken together, the results raise the possibility that NEDD4-family HECT E3s use a common, specific catalytic architecture for Ub ligation to various substrates.

Here we report that the second step of ligation is mediated by a distinct catalytic architecture established by both the HECT E3 and its covalently linked ubiquitin.

This may be stimulated by discharge of Ub from the HECT domain onto the substrate, which would diminish the number of contacts at the junction between the HECT domain N- and C-lobes, allowing the C-lobe to both face E2 and separate from Ub. Notably, our mutational data also suggest utilization of a common HECT domain catalytic architecture for both substrate ligation and Ub chain formation.

Here, cryo-EM and biochemistry show that the human E3 anaphase-promoting complex/cyclosome (APC/C) and its two partner E2s, UBE2C (aka UBCH10) and UBE2S, adopt specialized catalytic architectures for these two distinct forms of polyubiquitination.

The development of heterogeneous non-noble metal catalytic architectures that can realize the high selective and stable hydrogenation of nitroaromatics under mild conditions is a profound challenge in the catalysis community.

The dimeric state and an altered catalytic site architecture make d-PfFabZ distinctly different from the FabZ structures described so far.

Despite the shared catalytic core architecture of Sirt1 7, the development of small-molecule inhibitors and activators for them is at very different stages.

Alignment of reactants in the Michaelis complex and motion of the catalytic site architecture are necessary to achieve the transition state.

The three-dimensional structure of one of them, Rv0977 (PE_PGRS16) of M. tuberculosis revealed the characteristic pepsin-fold and catalytic site architecture.