Thus, a much higher number of samples than those currently obtained are needed to complete the catalog of driver mutations in human osteosarcoma.
The recognized incompleteness of the list of human TFs [ 11] and the catalog of driver genes – due to limitations built in the limit of detection of current methods [ 10, 13] – produces a repertoire of driver TFs that is not complete.
Second, uncovering the catalog of driver genes has revealed that at the level of genomic alterations, tumorigenesis possesses a very heterogeneous nature, with driver alterations in genes in the same pathway or in cross-talking pathways resulting in the same phenotype [ 2, 6– 8].
The catalog of driver genes involved in the development of several malignancies has grown in recent years, as a result of whole-exome and whole-genome analyses of cohorts of tumors, mainly within the framework of large international consortia [ 3, 4].
Exploiting the aforementioned catalogs of driver genes, for example, we recently revealed the mutational landscape of chromatin regulatory factors (CRFs) in cancer [ 5].
This catalog of mutational drivers included 459 genes.
There are two main reasons why the catalogs of cancer drivers produced by the aforementioned projects and others need to be broken down into related sets of genes for deeper analysis.
We report a substantial contribution to the catalog of SCNA-associated cancer drivers, identifying 147 amplified and 107 deleted genes as potential drivers, and derive insights about the genetic network architecture of aneuploidy in tumors.
As we draw closer to gaining more complete catalogs of candidate cancer driver genes in common forms of cancer, the landscape of somatic mutations in osteosarcoma is emerging from its first phase.
NORMALLY, Viisage Technology of Littleton, Mass., catalogs drivers' licenses and other forms of identification for government offices.
