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The MAb competed efficiently with the cat allergic patients' serum IgE for Fel d 1 binding in the competitive IgE binding assay, indicating allergenicity of the MAb epitope.
A study found that 63% of cat allergic people have antibodies against the protein.
The theoretical opportunity exists for the cat allergic patient to remove the source of allergen from the home environment.
This hypothesis would also be supported by the fact that cat allergic patients were less likely to be receiving other extracts.
While chronic allergen exposure has been shown to have deleterious effect, including enhanced airway remodeling, cat allergic patients treated with specific CIT may be protected from adverse outcome.
Cat allergic patients may be more motivated to undergo any treatment that is intended to reduce the likelihood they will need to eliminate a beloved pet.
Similar(53)
The investigation involved bronchial and skin biopsies and bronchoalveolar lavage (BAL) fluids from 8 cat-allergic subjects who developed significant late asthmatic reactions 6 hours after intradermal injection of Fel d 1 chain 1 derived peptides (FC1Ps).
It produced no adverse reaction when injected into cat-allergic mice and protected them from an injected dose of pure cat protein, report the researchers online 27 March in Nature.
This last finding may be biased by cat-allergic subjects tending not to own cats.
A double-blind placebo-controlled trial with 95 cat-allergic subjects was conducted using four subcutaneous injections of the peptide mixture (Allervax®CAT) or placebo [ 97].
No activation was seen upon stimulation of the two controls (a nonallergic individual and a cat-allergic patient without IgE to dog) (data not shown).
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