"cast significant doubt" is correct and can be used in written English.
You could use it to indicate that something has caused you to become uncertain or question the truth or legitimacy of a matter. Example sentence: "The miscommunication between the two departments cast significant doubt on the accuracy of the report."
But the CBO projections cast significant doubt on that claim.
But agency emails unearthed by Gizmodo have cast significant doubt on those explanations.
These lawyers, and other skeptics, may not have cast significant doubt on the legitimacy of the outcome.
"This fact indicates the existence of a material uncertainty which may cast significant doubt upon [Liverpool's] ability to continue as a going concern," they said.
Our results cast significant doubt on the ability of siderophore mutants to cheat in chronic infections, and therefore on their utility as Trojan horses.
That sequence of events is supported by data from Boeing and the British Inmarsat satellite communications firm but failure to find further wreckage will cast significant doubt.
Qualcomm did not contest the fine but it did express "disappointment" with the result of the investigation, which had been ongoing for more than a year and cast significant doubts over its business in China — although the company continued to make investments there.
"[This circumstance] represents material uncertainty that casts significant doubt upon the company's ability to continue as a going concern".
In the ITN annual report for the previous year the directors warned that the pension uncertainty "casts significant doubt upon the group's and company's ability to continue as a going concern".
But defence officials and experts agreed it was probable they had been separated over the past 13 months, casting significant doubt on the possibility that they were being held together as a group.
But now, a new analysis casts significant doubt on the previous weight estimate.
