As mentioned, the cases are aligned along two dimensions (see Table 1).
The structure of the cases is aligned with providing relevant, research-based and integrated materials that match the tenets of Vision and Change, wherein evolution is the basis for teaching and learning biological principles.
Conversely, the OS curve of discordant high (HER2 negative but H2T high, 9% of all cases) was aligned with concordant positive (HR = 0.41, P = 0.105), but showed a significantly shorter OS than concordant negative (HR = 41, P <0.0001).
The OS curve of discordant low (HER2 positive but H2T low, 10% of all cases) was aligned with concordant negative (HER2 negative and H2T low, HR = 1.9, P = 0.444), but showed a significantly longer OS than concordant positive (HER2 positive and H2T high, HR = 0.31, P = 0.024).
In all cases, sequences were aligned using MUSCLE v3.7 under default parameters [ 43].
In all cases, sequences were aligned using the Muscle algorithm [ 28], which were then confirmed by visual inspection.
In both cases, runs were aligned and peptide identifications were propagated between runs in order to minimize missing values.
Multiple sequence traces from control and case animals were aligned and compared using the phredPhrap program from the Consed package (www.genome.washington.edu).edu
In the former case, the two backgrounds were themselves misaligned (disrupting the gestalt cue of continuity) and were of different colors (disrupting the gestalt cue of similarity); in the latter case, they were aligned and of the same color.
In these cases, the genes were aligned using the MAFFT alignment tool and default parameters [ 113, 114].
