Sentence examples for cases the alterations from inspiring English sources
Many genes, however, displayed altered expression in both types of lesions, and in these cases the alterations were usually concordant in terms of direction, but those observed in the nonpolypoid lesions were less dramatic.
In most cases, the alterations resulted from C to T base changes in CpG dinucleotides.
In these cases the alterations were characterized by the presence of columnar epithelial cells with round to ovoid and/or hyperchromatic nuclei that were not perpendicularly oriented to the basement membrane, with a slight increase in the nuclear/cytoplasmic ratio.
In such cases, the alteration in network topology appears mainly driven by the effect of extreme prematurity, suggesting that these brain network alterations present at school age have their origin in a common critical period, both for intrauterine and extrauterine adverse conditions.
In many cases, the alteration of important elements of pathways has been validated by qRT-PCR.
In other cases, the alteration of genes or their rearrangement may be less harmful (only slightly deleterious).
In both cases, the alteration of the spatial domain of an existing gene expression pattern formed the basis of an evolutionary innovation.
It is intriguing to consider that ABO methylation may be part of a long range epigenetic silencing mechanism [51] leading to the co-ordinate silencing of a linked tumor suppressor gene may also be important in which case the alterations in ABO may be a sign post to a recurrent oncogenetic mechanism.
In this case the alterations in H MR spectra were reported to be associated with an accumulation of polyunsaturated fatty acids.
The expression of PDGFR-α varied between the cases with the alterations described above and did not show any correlation with the nucleotide alterations found.
Deletions at the chromosomal region 3p14.2 and TP53 abnormalities were present in 20% of the cases and the alterations were constantly associated (Marchetti et al, 1998).
