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In such cases, the alteration in network topology appears mainly driven by the effect of extreme prematurity, suggesting that these brain network alterations present at school age have their origin in a common critical period, both for intrauterine and extrauterine adverse conditions.
In many cases, the alteration of important elements of pathways has been validated by qRT-PCR.
In other cases, the alteration of genes or their rearrangement may be less harmful (only slightly deleterious).
In both cases, the alteration of the spatial domain of an existing gene expression pattern formed the basis of an evolutionary innovation.
Similar(56)
Many genes, however, displayed altered expression in both types of lesions, and in these cases the alterations were usually concordant in terms of direction, but those observed in the nonpolypoid lesions were less dramatic.
In most cases, the alterations resulted from C to T base changes in CpG dinucleotides.
In these cases the alterations were characterized by the presence of columnar epithelial cells with round to ovoid and/or hyperchromatic nuclei that were not perpendicularly oriented to the basement membrane, with a slight increase in the nuclear/cytoplasmic ratio.
In each case, the alteration in phenotype was associated with the same 58 bp deletion upstream of tetM.
Interactions between exposures and genetic alterations in tumors were tested with logistic regression models comparing cases with the alteration to cases without it.
The ability of tumor cells to invade is an acquired and progressive phenomenon mediated, in many cases, by the alteration of membrane glycoproteins such as mucins.
The fact that many breast cancer cases with the alteration (Ala592Thr) in the present study were of the ductal comedo type may indicate a genetic basis for the phenotypic divergence caused by this germline E-cadherin alteration.
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