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Taken together, these results indicate that in some isolated cases, specificities of orthologous TFs can diverge over long evolutionary time.
Although they gave similar sensitivity to the above for identifying GCK-MODY cases, specificities were much lower at 42, 58, and 66% for A1C, FPG, and the combined criteria, respectively.
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For all culture negative cases, specificity was 92.3%.
However, in a few cases, specificity was reduced in the dimer probes.
In favorable cases specificity has been designed by focusing only on interactions with the target protein, while in cases with closely related off-target proteins it has been necessary to explicitly disfavor unwanted binding partners.
Theta band SL accurately classified 69% of cases; specificity was 76%, while sensitivity was 62% (see figure 4 for ROC curve).
Clinical sensitivity and in some cases specificity has been disappointing.
The basic keyword search detected 58% of cases (Specificity 0.99), an index search detected 62% of cases (Specificity 0.87), and the content analytic text mining (using adjusted probabilities) approach detected 77% of cases (Specificity 0.95).
In both cases, specificity was assessed by using the probes described above.
A cut-off score of 83.3% optimally identified 100% of ESRD cases (sensitivity) and 46.7% of non-ESRD cases (specificity).
The 72 hour model predicted treatment failure and success correctly in 24/30 (sensitivity 80%) and 173/222 cases (specificity 78%), respectively.
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CEO of Professional Science Editing for Scientists @ prosciediting.com