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The team, led by Jay C. Fournier and Robert J. DeRubeis of the University of Pennsylvania, found that compared with placebos, the drugs caused a much steeper reduction in symptoms of severe depression (cases scoring 25 or higher on a standard scale of severity, putting them in the top quarter of the sample).
We could test this, because our enquiry included HADS; this enabled us to compare, for prevalence of interictal anxiety, those with HADS-A scores in the normal range (<8), borderline cases (scoring 8 10) and those at or above the threshold score (11) for anxiety caseness [18].
Cases scoring less than 50 were removed.
Cases scoring 0 and 1+ were classified as negative.
The number of cases scoring 0 increased from 3%to25%5% (p <0.001), while the number of cases scoring 3 decreased from 32%to10%0% (p <0.006).
Cases scoring 0 3 were regarded as negative from the point of view of endocrine therapy, whereas cases scoring ⩾4 were regarded as positive.
Similar(34)
Following established practice, we categorised women's scores to indicate 'non-cases' (scores 0 7), 'possible cases' (scores 8 10) and 'probable cases' (scores of 11 or more) (Fayers and Machin, 2000).
Concerning severity, most (85%) cases scored 3 or 4 on the NACA scale.
All other cases scored zero points.
Eight cases scored as 2+/3+ evaluated by FISH showed amplification.
Cases scored 0 and 1+ were classified as negative, and cases scored 3+ were classified as positive.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com