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We analyzed 137 studies that together report on 76 cases of intensification and 143 cases of disintensification.
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Three cases of process intensification are studied to evaluate the principle, including: (i) a hypothetical reactive distillation system; (ii) a reactive distillation column for the hydration of ethylene oxide; (iii) an ideal heat-integrated distillation column.
A residue curve maps (RCMs) is developed to analyze the mechanism of intensification for the case with two reactions and multiple components.
The second section examines six case studies covering a long gradient of intensification, where we highlight how the different principles can combine to generate environmental, social and economic benefits.
The underlying reasons for the yield gap and the implications of intensification have mostly been analysed in case studies [ 66].
Some experimental case studies using industrially important reactions have been presented, highlighting the degree of intensification achieved as compared to the conventional approaches.
To examine the sensitivity of the findings to these assumptions, and to better understand the relationship between initial treatment decisions and the level of intensification administered through follow-up care, three additional clinical trials were simulated: Low-intensification case: patients not at goal were three times less likely to intensify treatment as in the main study.
As intensification pathways become dominant globally, new, sustainable modes of intensification are urgently needed.
As expected, worse glycemia was an important predictor of intensification.
This adaption could potentially take the form of intensification or de-intensification of treatment based upon early response.
The units considered are batch reactor to serve as the base case, and process intensification of integrated reaction–separation by simple reactive batch distillation (using a batch reactor condenser arrangement) and by a multi-stage reactive batch distillation column with partial reflux.
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