Of the 91 patients with both aCGH and FISH results, aCGH detected 11.0% (10/91) of CNAs that were not detected by FISH [6 cases of del(13)(q14), 2 cases of del(17)(p13), and 2 cases of gain(1)(q21)].
On the contrary, I-FISH detected 11% (10/91) of abnormalities not identified by aCGH [2 cases of del(13)(q14), 3 cases of del(17)(p13), and 5 cases of gain(1)(q21), resp.].
Some of the near-CN-LOHs in the primary tumors were found in the regions of 1 p and 11 q and some cases of gain-LOH were also found in the region of 17 q.
However, if intron gain was, indeed, episodic in eukaryotic in eukaryotes as suggested in this paper and previously elsewhere (ref. 50), such unequivocal cases of gain are likely to be very few and far between, and this seems to be so.
However, rare cases of gain or amplification of the derivative chromosomes or episomes carrying the fusion gene have been reported [ 25- 27] and gene dosage effect of the fusion gene can improve the tumor growth resulting in more aggressive course of disease [ 27].
This section explores cases of gain-of-function in p300/CBP, either by direct mutation or overexpression of p300/CBP or by the involvement of p300/CBP in the disease etiology, as well as additional instances where disruption of p300/CBP activity would be therapeutically advantageous (see Figure 19).
Władysław promised not to sign any pacts against the Habsburgs, and to transfer his rights to the Swedish throne in case of his line's extinction; in return, Habsburg promised to support his efforts to regain the Swedish crown, and to transfer to him some territory in case of gains in a war against the Ottomans.
The same argument applies in the case of gains and a negative location bias.
In the case of GAIN, Founder and CEO Nick Gammell said that, initially, the teams' focus was solely on the Web.
