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They focus on two particular cases of factors involved in cancer progression and among their targets on particular potential anti-apoptotic representatives.
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In cases of factor V deficiency where factor concentrates are not available long term use of fresh frozen plasma can prevent potentially life threatening bleeding.
In the present case of factor XI deficiency, supplementation with clotting factor and proper anesthetic management were important to prevent severe complications.
In the case of factor analysis, the aim is to create a factor model that balances complexity (number of factors) with the amount of variance explained.
The closest distance between the S−F α-helix and the 695−698 region was found to be ∼24 Å in the case of factor Va3K as compared to ∼33 Å in the case of unmodified factor Va.
In contrast, in the case of factor VaAA and factor VaKF, the β-sheets are extended at the V and K ends by three amino acids.
A study of 61 patients with PVT from India reported only 1 case of Factor V Leiden and none with prothrombin gene G20210A mutation [ 34].
However, in the case of factor Va3K, the S−F α-helix and the R−V/K−T β-sheet appear to be unaffected by the mutations.
In the case of factor XIII a, the activated enzyme contains a single calcium ion in a position near to the catalytic site (Fox et al. 1999) though its binding does not markedly alter the structure.
The MD data show that the antiparallel β-sheet contained in the region from R to V (first strand) and K to T (second strand) is preserved in the case of factor VaWT during the simulation.
Only seven cases of experimental factors are considered because of the difficulty in producing samples and the manufacturing cost.
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