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Overall, no cases of CHF were reported.
Moreover, the frequencies of novel cases of CHF arise progressively worldwide [2].
In a phase II study involving 64 patients with MBC treated with sunitinib monotherapy, no cases of CHF were reported, but 6% experienced grade 3 hypertension [ 79].
There was little difference between liposomal doxorubicin and epirubicin for subclinical cardiotoxicity, and any cardiotoxic event RR 1.15 (0.47, 2.84; p = 0.754); no cases of CHF were reported in either group.
Given the small number of reported cases of CHF (for the overall comparator analysis, n = 12 and n = 9; and for the comparison with placebo only, n = 9 and n = 5), the reported HR of 1.04 (95% CI, 0.43 2.47) in the overall comparator analysis, or 1.29 (95% CI, 0.43 3.87) in the placebo-only analysis must be interpreted with some caution.
In the United States, more than 400,000 new cases of CHF are identified each year and added to the estimated 2.5 to 5 million Americans with prevalent CHF [ 11, 12], yielding an overall prevalence of 1.1% to 2% of the population.
Similar(53)
In the case of CHF management, lack of knowledge appears not to be very pertinent [ 10, 11].
In the case of CHF, the largest differences were observed for 'income inequality' where 223% higher risk was observed in bottom ranked counties.
In the case of asthma, exposure on the day of the visit was chosen as the best fitting model while in the case of CHF, the day prior to the visit was the main exposure variable.
In the Herceptin Adjuvant trial (HERA), with 3.6 years of median follow-up, all cases of severe CHF occurred during trastuzumab treatment; however, the cardiac condition of the majority of affected patients improved when trastuzumab was withdrawn [ 15].
In the Herceptin Adjuvant trial (HERA), with 3.6 years of median followup, all cases of severe CHF occurred during trastuzumab treatment; however, the cardiac performance of the majority of affected patients improved when trastuzumab was withdrawn [ 32].
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