Exact(1)
Most cases of activation or suppression of gene expression detected by microarray were also observed by RT-PCR, although the degree of the response was different for some genes (Supplementary Figure S2).
Similar(59)
One potential explanation for the upregulation of anti-inflammatory type 2 cystatin proteins in prostatitis is the body's attempt to regulate the inflammatory response and prevent excessive tissue destruction, similar to the case of activation of hemostatic pathways, which activate fibrinolytic proteins to prevent excessive clotting.
These enzymes are usually synthesized as inactive precursor zymogens that are cleaved to generate their active forms in the case of activation sites being recognized during limited proteolysis.
Moreover, in case of activation by optimum MS ratio, sodium silicate activated AAS mortars present higher compressive strength, lower water absorption, higher workability, lower porosity and a wide range of setting times compared to NaOH activated AAS mortars and Portland cement mortar.
For the case of activation, which we are considering here, the active state corresponds to all binding sites being filled, and so the rate at which the system leaves this state, k−, should not depend on the concentration of the transcription factors.
CD62p (140 kD) is a granule membrane protein, exposed on the PLT surface membrane in the case of activation.
In case of activation of the GPCR, a conformational change of the receptor results in an exchange of GDP for GTP at the G alpha subunit.
Moreover, due to the important amount of genes expressed in case of activation, immune cells are relevant for revealing significant parts of the host transcriptome.
In the context of prokaryotic transcription, a TF is known to bind upstream of the transcription start site and often upstream of the −35 promoter element in case of activation.
Close proximity of the IP3R-enriched SR elements to the cell plasma membrane facilitates an abrupt IP3R-mediated Ca2+-release when [Ca2+]i and [IP3]i rapidly rise in the restricted microvolume between the SR and plasmalemma, as observed in the case of activation of muscarinic receptors with CCh (Fig. 8C).
In the case of activation by HRP via one-electron oxygenation, it is possible that there could be constant recycling of the semiquinone back to paracetamol with little formation of NAPQI, provided there is sufficient GSH or NADPH (preferentially GSH (Potter and Hinson, 1987)).
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