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For the 12 studies prospectively adjudicated by MHI, the sponsor identified potential cases for adjudication based on AEs and SAEs with PTs that correlated with the following Standardized MedDRA Queries (SMQs) groupings, as defined by the current version of MedDRA: "ischemic heart disease" (adjudicated for possible MI) and "cerebrovascular disorders" (adjudicated for possible stroke).
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Because of the innovative nature of the marketplace, the framework should not involve anticipatory rulemaking, but rather principles that allow for case-by-case adjudication.
If there was any disagreement between ratings (e.g., ADE/No ADE) or uncertainty (e.g., ADE/Uncertain), an independent committee consisting of a clinical pharmacist and a medical toxicologist (who was also a physician), both of whom were otherwise not involved in the study, adjudicated the cases (See Algorithm for adjudication committee, Additional file 1).
Modern scholars agree: a belligerent could apprehend a neutral ship carrying enemy goods, but must present the case for proper adjudication in port.
Only case-by-case adjudication developing "the common law" can fill the vacuums left by craven legislatures.
First, she appeared skeptical about whether the case is ripe for adjudication.
The Supreme Court dismissed the case on technical grounds, holding that the case was not ripe for adjudication.
The primary reason for non-adjudication also was inability to locate the patient's medical record (n = 45); other reasons included inability to identify a care provider in the Medicaid files (n = 20), inability to obtain records from providers that relocated or were no longer practicing (n = 11), provider refusal (n = 4), and insufficient information for case adjudication (n = 3).
The committee said it was the "gravest case" which has come to them for adjudication.
An officer will now send a summary of the case to competition commissioner Neelie Kroes for adjudication, with the maximum penalty being a fine of 10% of the companies global turnover.
Although laboratory values were required for adjudication of a case as diabetes [ 36, 37], standardized fasting glucose or glucose challenge tests were not uniformly obtained.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com