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Whilst haemorrhagic tumour necrosis has been noted on MRI in the literature, none of the cases evaluated with MRI in our cohort demonstrated lesional T1 hyperintensity or T2 fluid-fluid levels to suggest the presence of haemorrhage [19, 20, 22].
Thus we cannot differentiate between those cases evaluated with one method or the other nor those GA corrected by USN and those not.
Third, the QUADAS tool revealed that in approximately two-thirds of the studies partial verification bias was not clearly avoided, as not all cases evaluated with the index test went on to receive verification using the reference test.
Consequently, thirteen original research reports (as listed in Table 1 below) and a total of 2920 NPC cases evaluated with MRI were included in this analysis [ 7, 8, 12- 14, 19- 26].
In approximately one quarter of the studies, partial verification bias was not clearly avoided as not all cases evaluated with the index test were verified using the reference test.
Nevertheless, the mutation frequency in rectal GISTs has not been specifically investigated [ 15, 16] except in Miettinen's study [ 8], which found mutations in 18 of 29 (62%) of the cases evaluated, with a predominance of KIT exon 11 mutations, a lack of KIT exon 13 mutations, and only one KIT exon 9 mutation.
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For the case evaluated with recycle intercooling, the new design achieved significant packing reductions (>50%) compared to a simple intercooling design and approximated the performance of an isothermal column.
For example, Hilson and colleagues [ 10] found that expression of MEC markers such as smooth muscle myosin heavy chain, CD10 and cytokeratin 5/6 was reduced in the MECs surrounding DCIS in over 80% of the cases evaluated when compared with MECs in normal breast tissue.
For quantification only cases with nuclear protein expression were considered PXR positive, with cases evaluated as positive for PXR when more than 2% of counted cells showed nuclear positivity of PXR protein.
The anti-PLA2R antibody is described as negative in all cases evaluated in MN associated with IgG4-RKD [ 8] and was also negative in this patient, although the result was obtained from the serum 3 years after the diagnosis of idiopathic MN and after corticosteroid therapy.
For validation of the lobule type analysis, a total of 70 cases were evaluated with a minimum of 10 normal lobules for each lobule type analyzed per case, except in cases in which fewer than 10 lobules were present where all available lobules were included.
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