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In a few more cases, distant putative paralogs can be detected using the z-score measure.
In 28% (n = 5) of cases, distant disease presented synchronously with regional nodal disease.
These recurrences were local only in 26 cases, distant only in 12 cases, and local and distant in 6 cases.
In these cases, distant metastasis was the primary cause of failure [ 21], which was consistent with the result of the present case study.
Neuroblastoma is clinically variable with some tumours demonstrating spontaneous regression after little or no therapy, while in other cases distant metastases are present at diagnosis.
In addition to locally advanced cases, distant metastasis at the liver and in the peritoneal cavity may be a clinical target of local IFN- α gene therapy.
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Only in one case distant metastases could be evaluated.
In this case, distant metastases were seen in the anterior chest wall and scalp 2 months after local recurrence.
Even if this is the case, distant regulatory elements, such as enhancers, have been identified in a variety of bacterial taxa (Xu and Hoover 2001).
Relapses occurred at the site of the primary tumour in five cases, at distant sites in seven, and both locally and at distant sites in four cases.
All examined tumors were surgically removed so none of the cases had distant metastasis therefore our cases ranged from Stage I to III.
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