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Histopathological typing of carcinomas was classified into three groups; well (21 cases), moderately (23 cases), and poorly (five cases) differentiated carcinoma groups.
Liver metastases were also categorized according to differentiation into well (G1; two case), moderately (G2; twenty-five cases), or poorly (G3; seven cases) differentiated carcinomas (Table 3).
HCC samples were categorized according to differentiation into well (G1; seven cases), moderately (G2; nineteen cases), or poorly (G3; seven cases) differentiated types, which correspond to Edmondson's Grades I/II, III, and IV [ 21, 22].
I stage six cases, II stage 32 cases, III stage 14 cases, IV stage eight cases (NCCN Classification Standard); well differentiated 17 cases, differentiated 31 cases, poorly differentiated 12 cases.
In these cases, differentiated cells likely contain the same genetic mutations as the self-renewing cancer stem cells, but are arrested at different stages of cellular maturation (Magee et al., 2012).
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Histopathologically, 71 cases were differentiated (papillary, well-differentiated and moderately differentiated tubular adenocarcinoma) and 104 were undifferentiated (poorly differentiated adenocarcinoma, mucinous adenocarcinoma and signet-ring cell carcinoma) carcinomas according to the 7th edition of tumor node metastasis classification.
Tumor grade was divided into 3 groups: well-differentiated (grade I, 31 cases), moderately differentiated (grade II, 74 cases), and poorly differentiated (grade III-IV, 55 cases).
In 634 cases well-differentiated to moderately differentiated tumors, 235 (37.1%) of the cases had positive MTSS1 expression in GC tissue; whereas in 438 poorly differentiated tumors, only 86 (19.6%) presented positive MTSS1 expression (P < 0.001).
EBV association is constant regardless of patient origin and tumor differentiation except for some rare cases of differentiated NPC (type I) in Western countries [ 3].
A few cases are differentiated (WHO types I).
In conclusion, in cases of differentiated EPT, SRPET is the first-line examination, except if Ki-67 >10 % favours FDG PET.
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