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The same procedure was used to compare samples from patients who were asymptomatic but had eosinophilic infiltrates in their muscle biopsies (2 cases) and samples from healthy controls (10 cases).
Here we report the results of a more detailed study involving a larger number of cases and samples including controls.
Gene expression data were available for all 346 cases, and samples were classified according to PAM50 gene expression subtypes (Table S1 in Additional file 1).
Given a fixed time t, the instances for which t i = t are regarded as cases and samples with t i > t are controls.
Each participant provided a one-time 10 ml of venous blood sample (after the diagnosis and before the initiation of treatment for the cases), and samples were kept frozen till DNA extraction for genotyping.
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Future work will focus on a broader set of use cases and sample data.
GW collected the cases and sampling and helped to draft the manuscript.
QL collected the cases and sampling and helped to draft the manuscript.
DAH and WHO are involved in the recruitment of cases and sample collection.
For all qualifying studies, extracted data included study country, year of study, diagnostic test used for confirmation, total number of H. ducreyi positive cases, and sample size.
Bacteria were not found in 4 (8.3%) samples from such cases and two samples were contaminated.
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