In this case, all the efforts will have been in vain.
In any case, after all efforts to improve internal fixation it became evident that the failure rate in displaced fractures was still not acceptable.
If, however, the aim is to confirm the equivalence of two (or more) treatments (which is the case in all efforts to reduce or stop medication), the N-of-1 trial is an equivalence trial, and requires a different method of analysis, with a strong emphasis on the definition of a minimal important difference, and sufficient observations to enable equivalence testing.
14 In all cases, any efforts aimed at discovering new halogenases 10 or genetically reengineering existing enzymes 15 require the capacity to detect and quantify halogenation activity.
In case of disagreement, all efforts must be made to reach agreement.
Therefore, in case of discontinuation, all efforts will be made to complete and report the observations as thoroughly as possible.
In all cases, efforts were made to achieve optimum positioning of the tip of the screw in the subchondral bone of the femoral head with a combined tip apex distance measuring <25 mm on anteroposterior and lateral radiographs.
In all cases, efforts were made to ensure even seeding of hESC across the well, relatively uniform colony size, and an absence of large clumps of cells.
In all cases, efforts were made to achieve optimum positioning of the tip of the screw in the subchondral bone of the femoral head with a combined tip-apex distance less than 25 mm on anteroposterior and lateral radiographs as postulated by Baumgaertner et al [ 18] Distal locking screws, which are possible in dynamic or static position, were not routinely used.
Of course, there's Greece, a special case where, despite all the efforts that have been made, neither the Greeks themselves nor the international community have yet managed to stabilise the situation".
