Case studies have described an association between repetitive ajmaline administration and liver injury, with the typical pattern identified being that of an initial acute hepatitis followed by a prolonged period of cholestasis [ 7- 9].
Since the correlation between mutations of the glycosyltransferase POMGnT1 in patients with MEB was discovered almost a decade ago [ 22], a continuous stream of case studies have described more than 25 independent homozygous mutations distributed throughout the 21 exonic regions of the POMGnT1 locus [ 32].
Regarding the factors associated with unreported TB cases, studies have described high rates of unreported cases among older patients [ 10, 13], among those without microbiological confirmation [ 10], among patients with absence of cavitary lesions on chest x-ray [ 10, 13], and among non-immigrant patients [ 13].
A retrospective case control study has described the effect of autologous platelet gel applied to exposed tissues, synovium and the lining of the wound at closure following total knee arthroplasty [ 55].
Case study has been described as a 'study of the particular' (p XI) [ 2] as it is allows for the study of highly context-bound phenomena with a multiplicity of variables not amenable to control.
In many cases, human studies have described the presence and allowed phenotypic characterization of the different cell types, whereas mouse models have been invaluable in defining the functional contribution of these cells.
Since the initial report, a number of studies have described further cases of 22q13.3 deletion syndrome with disruption or deletion of SHANK3.
Is important to highlight that, institutions routinely using HME should be aware of obstruction events and cases of hypercapnia and hypothermia, because some studies have described their occurrence.
Population-based case control studies have described a two to three-fold increased risk in first-degree relatives of ovarian cancer patients (Godard et al, 1998; Stratton et al, 1998) and heritability is estimated to be approximately 22% (Lichtenstein et al, 2000).
