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The two nonsynonomous SNPs were found to be over represented in the case pool compared to the control pool with the N417Y variant reaching a level of statistical significance.
This resulted in a mean coverage of 228 reads per position for each individual in the case pool (114 per allele) and 197 reads per position for each individual in the control pool (98 reads per allele).
The only SNPs that were identified in both the 1000 genomes data and our data are the SNPs at positions 158588123 and 158587689 which both have a minor allele frequency of 0.035 in the case pool and 0.048 in the control pool.
Each case pool was assayed on duplicate microarrays.
The final case pool (n = 843) included 64% of the cases diagnosed between 1980 and 1986.
Figure 7A shows the PoolingPlanner input panel for the case pool; Figure 7B the input panel for the control pool.
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The distributions of APOE alleles in this population are as follows: Pooled fcas: Predicted Allele Frequency in MRC Case Pools.
Now, as then, Wall Street firms and entrepreneurs made fortunes issuing questionable securities, in this case pools of home loans taken out by risky borrowers.
First, the test suite is created by selecting a specific number of test cases from test case pools.
In case pooling of data was considered we assessed the following sources: classification of headache, age, site of measurement, and measurement units.
In this case, pooling experimental and observational data increased the power and external validity of the findings.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com