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DALY losses, cost of illness per case and cost of the different vector control strategies were computed using base case parameters values reported in Tables 1 and 2. Details can be found in the Appendix S1.
Teams will work with the instructor at the outset of the course to select and customize the case parameters to match the ERM curriculum paths of the case team.
The PBE model satisfactorily accounted for changes in the dispersed phase volume fraction and the interfacial tension with the base case parameters.
In order to stabilize the inverse estimation, it is essential that a regularization term is included in the objective function in case parameters are estimated zone-wise.
Model extensibility to different emulsion compositions and homogenizer pressures was investigated by comparing model predictions generated with the base case parameters to drop volume distributions measured under different conditions.
For the same base case parameters and operating conditions, the average current density of ASC is 6388 A m−2, only 83% of the ACSC, 7713 A m−2.
Similar(32)
In such condition optimal input sequences minimizing the worst case parameter uncertainties are derived.
In any case, parameter estimates will have uncertainties that will be important to assess when predicting future scenarios.
For base case parameter values, the estimated out-of-pocket cost per approved NCE is $114 million (1987 dollars).
As discussed above for the linear case, parameter C controls the complexity of the estimated function.
In each case, parameter estimation is based on the assigned Δ E sample with 345 values.
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