Previous case-control study on a large sample of blood donors has shown that RhD-positive heterozygotes are resistant to pathological effects of toxoplasmosis while RhD-positive homozygotes are only temporarily resistant: their psychomotor performance decreases with length of infection.
It analysed the effect of age at menarche, age at first full-term pregnancy, number of full-term pregnancies and number of spontaneous abortions both on the overall risk of breast cancer and on its pre- or postmenopausal onset, using the data on 1718 breast cancer cases, obtained from a large sample of around 100 000 French women participating in the E3N cohort study.
Estimate the complication rate on a large sample size.
In India, poverty counts are based on a large sample survey of household expenditures.
Then you could evaluate the approach on a large sample.
If expression of these genes can be shown to be consistently altered in LCL in case-control studies on a larger sample of unrelated individuals, these cells, and by inference their precursor blood lymphocytes, can potentially be used as reporter cells for diagnosis of ASD.
In any case, a larger sample is certainly required for a more powerful replication study.
Surprisingly, our quantitative data also suggest that larger axons may have thinner myelin sheaths, however further study on a larger sample of cases would be required to confirm this finding.
Our results were based on a larger sample (3,372 cases) and a longer follow-up period (12 years), and we adjusted our estimates for a wide variety of well-established contributors to diabetes risk, including family history, multiple lifestyle factors, and BMI.
The strengths of our multicentre study include its prospective and population-based design, detailed information on diet, large heterogeneity in flavonoid and lignan intake and a large sample of bladder cancer cases, with validated information on tumour aggressiveness.
