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The Payne decision explicitly disclaimed any effect on the basis of the Booth case, of recommendations by relatives on what punishment the defendant should receive, since that issue was not raised in the Payne case.
And in the case of recommendations on the conduct of clinical studies, stakeholders such as pharmaceutical companies and registration agencies are important to include in the evaluation process.
Pointing to the case of recommendations in the 1990s to reduce fat intake to less than 30% of one's daily calories, it was not anticipated that dietary choices that were intended to reduce fat would translate into higher carbohydrate and calorie intakes.
For example, in the case of recommendations for metformine prescription, the guidelines merge "renal insufficiency (yes/no)" and "body mass index (BMI) ≥ 28 (yes/no)" into a new attribute of "no renal insufficiency and BMI ≥ 28 (yes/no)" such that only a single (composite) condition has to be verified prior to metformine prescription.
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Another dissemination option is to send the recommendations to a high number of the target population, for example, rheumatologists in various countries in case of management recommendations.
The impact is broader in the case of new recommendations than in the other outputs.
However, in the case of many recommendations the how, by whom, and under what conditions they can be implemented is not specified.
In case of management recommendations, these could be rheumatologists working in various countries in academic and non-academic centres.
The databases that will be used for the search should be defined with a minimum inclusion of MedLine/PubMed and the Cochrane Library (the latter in case of management recommendations).
The overlap between the pathway and the German CHD Disease Management Program DMPP) as systematic treatment program for chronically ill people [ 6, 39] was seen as an impeding factor for the pathway implementation in cases of differing recommendations.
This is the case of the present recommendations on cable stayed bridges or other references for evaluating the dynamic effects produced by the accidental loss of a segment during the cantilever construction of a precast concrete bridge.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com