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The researchers documented that there was negligible expression when the consensus bases at positions −3 and +4 were mutated, while in case of mutation only at position −3, there was a seven fold reduction in the expression levels.
In the case of mutation, the rate at which resistance develops can be attributed to the rate at which bacteria mutate.
We identified 9 cases (8%) of Flt3-TKD mutations (5 cases of mutation D835Y, 3 cases of mutation D835H, and 1 case of mutation Del836), and no cases of Flt3-V592A mutation.
In case of mutation, two positions are changed randomly for all the periods.
For example, (iii Substitution, a special case of mutation, replaces a single operator with a type-wise compatible one.
In the case of mutation operators, we use the inverse order of correspondence since the lower the correspondence more difficult the specific fault types to be detected by automatic static analyzer and the mutation operator should be considered during testing.
Similar(47)
A good example is the case of mutations in E21, which can be mutated to either G or K, similar to mutations in E100.
In case of mutations in EYS genes, high prevalence has also been observed among Spanish population14, Americans with European origin13 and among Japanese populations60.
However, the ability of the mutants to form surface biofilm was significantly lesser in the case of mutations in the three central positions of the signature domain.
Obviously, this hypothesis makes sense in the case of mutations altering the polymerase DnaE.
Without a controlled vocabulary or a clear definition of what constitutes an activating mutation, especially in the case of mutations with multiple known phenotypes, systematic identification will continue to be a challenge.
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