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In case of lesion number HPV16.12, HPV16 was the type detected at both baseline and in the biopsy.
In our study one false positive result was a case of lesion with diameter of 1 cm suspected to be a metastasis.
In case of lesion number HPV18.1, HPV18 was detected at both baseline and in the biopsy, the latter contained HPV16 as well.
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Furthermore, in case of lesions with both solid and cystic components, a consensus on localisation of ROI (in solid or cystic part of lesion) should be established.
This better delineation of tumors was particularly useful in the case of lesions harboring heterogeneous tracer uptake, as shown in Figure 6 in a mouse with a necrotic tumor near the bladder.
The largest area under curve (AUC) with high sensitivity and good specificity has been obtained for kep, Ktrans and HR, in the case of voxel-by-voxel analysis and for D∗, WIS, and f, in the case of lesion-by-lesion analysis (we discarded SB because of very low sensitivity).
In case of lesions suspicious for distant metastases, histological or cytological confirmation is attempted.
In our study in case of lesions with macrocalcifications microcalcifications were also identified in half of cases.
Biopsy consistently gave the highest diagnostic yield with the possible exception in the case of lesions smaller than 2 cm.
In the case of lesions in more than one location, the most severe one counted in the classification.
In our study, a 'one-stop shop' process – using one colonic preparation for capsule endoscopy, followed by colonoscopy in case of lesions, requiring very rapid reading - was not attempted or done (and this was explained to patients during informed consent).
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