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Runners will be censored in case of: discontinuation of the running schedule due to lack of motivation and/or time, health- and illness problems, and other personal concerns hindering further participation.
In the case of discontinuation, the patient incurs a treatment specific risk of suffering from discontinuation symptoms.
Therefore, in case of discontinuation, all efforts will be made to complete and report the observations as thoroughly as possible.
This might be relevant in case of discontinuation of therapy early in a quarter or when patients received a PEP.
In the case of discontinuation of the antidepressant, the report also asked whether the HCP has been informed.
In case of discontinuation, 16 (46%) patients received a second line treatment with either oxaliplatin plus a FA/5-FU consisting regimen or an epidermal growth factor receptor antagonist.
Similar(52)
The authors of the meta-analyses pointed out bias in the selection of candidates for treatment, limitations related to the number and type of adverse effects and their clinical evaluation, and in the cases of discontinuation of treatment or loss to follow-up.
All cases of discontinuation due to nausea during this period (eight patients) occurred in dulaglutide arms.
The majority of cases of discontinuation or switching of statins resulted in hospitalisation accompanied by acute changes in renal function.
Dropout patients were handled in the following way: if the reason for discontinuation was the inefficacy of the therapy, patients were considered as non-responders; for all other reasons, in case of early discontinuation, a prevalence approach was adopted.
In case of effect, discontinuation should be attempted every 6 12 months to confirm that the patient still needs the medication and that the medication remains effective.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com