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In our analysis, the three living Balearic Garden Dormice depicted an original case of differentiation.
Consider a case of differentiation into three cell types.
To our knowledge, however, P. muralis is the first reported case of differentiation into multiple refugia within all Mediterranean peninsulas.
As in the case of differentiation, reprogramming has been viewed as a stochastic process because of its inefficiency 52, but these observations originate from studies of functionally heterogeneous populations in which reprogramming is a rare event.
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In the case of vasculogenic differentiation, low oxygen concentration controls the differentiation potential of human peripheral mononuclear cells, bone marrow CD133+ cells, and mESCs (Berthelemy et al, 2009; Ong et al, 2010; Purpura et al, 2008); however, the underlying molecular mechanism remains unclear.
However, in the case of myogenic differentiation, where many genes are differentially expressed, this assumption does not hold.
This flattening of the differentiation rate appears to be particularly pronounced in the case of erythroid differentiation, in which the major part of total displacement from initial state is accomplished in the first time step.
In the case of erythroid differentiation, activation of PI3K/AKT is not merely an association, since blockade of this pathway inhibits differentiation [26], [27], [28].
The question of whether this case of ecological differentiation occurred in sympatry or allopatry remains open.
In case of low differentiation, population structure is usually due to variations in allelic frequencies.
Decreased levels of ANCR have been reported in the case of osteoblast differentiation by Zhu et al.
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