Require: In case of update, an item pair identified by a and b, and diff δ a, b, δ a, b ″ ; or in case of deletion: an item pair identified by a and b, and −δa,b.
In the case of deletion 5, 12, 6, 8 and 677, a few base pairs of the 5'P inverted repeat sequence and in the case of deletion 6 also a few base pairs of unknown origin had stayed behind after the imprecise excision of the P{lArB}.
In case of deletion, a similar imbalance was found, but in the opposite direction, i.e. about 60% of the variant proteins showed decreased expression, while only about 40% were over-expressed (Figure 2A).
Nevertheless, several CHS paralogs can be partially redundant and can complement each other in case of deletion of one paralog.
If B allelic frequency and signal intensity were simultaneously used to discover CNV in the case of deletion and duplication, the identification would be more accurate.
A segmental chromosomal alteration was defined as either the presence of an aberration of the respective chromosome arm, as determined by FISH, or in the case of deletion or imbalance, as determined by LOH.
In case of deletions, the deleted segments were re-inserted in the human sequence and all overlapping codons were translated.
Such information has predictive value in the case of deletions or insertions, and is generally more reliable with increasing lesion size.
In case of deletions in GSTM1 and GSTT1 genes, a lack of enzyme activity is evidenced.
In the case of deletions, the remaining alleles were simply the genotype values called in GenomeStudio.
A similar trend was observed in the case of deletions originating in the adaptive recovery phase.
