In two of the five cases, manifestation of palmoplantar pustulosis was not accompanied by worsening of plaque-type psoriasis.
The onset took the form of cerebellum ataxia associated with fever in 4 cases, digestive manifestations in other 4 cases and 1 case presented flu-like syndrome.
In our case, some manifestations such as the liver enzyme increase could partially be attributed to the previous administration of co-trimoxazole.
In this study of dCJD cases, we have reported that infratentorial grafting cases in not only the sample population as a whole but also the non-plaque-type cases developed manifestations related to dysfunction of the brain stem and cerebellum more frequently than did the supratentorial grafting cases.
Some of present cases exhibited manifestations similar to psychiatric criteria for social anxiety disorder, while most manifested embarrassment as a side effect.
In these cases neurological manifestations may vary widely.
Moreover, in some cases, clinical manifestations can differ among members of the same family.
If the individual cannot cope successfully, he or she cannot be mentally resilient against hazards; in this case, the manifestation of symptoms of psychological dysfunction, such as diseases, social disengagement, and criminal activity are likely (Werner and Smith 1992).
In a few cases, extracolonic manifestations were the first noticeable changes.
In severe cases, hemorrhagic manifestations may appear as early as 3-6 days following disease onset.
