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Margolies raises a red flag: Fannie Mae and its cousin, Freddie Mac, may not be prepared for "systemic risk"–in this case, disruption in the mortgage market.
If this had been the case, disruption of iab-6 should not interfere with this simple de-repression mechanism.
In the latter case, disruption of the native disulfide bond likely contributes to the observed misfolding and aggregation.
In that case, disruption of embryonic WGA-G by chs-1 RNAi might also prevent MBK-2 localization.
If this is the case, disruption at the level of transcription could occur via several mechanisms leading to different outcomes.
Studies with pseF, pseG, and pseH mutants were also conducted in C. jejuni to verify their role in pseudaminic acid production, and in each case, disruption of these genes resulted in nonmotile phenotypes because of the lack of flagella filaments and hook structures.
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Paediatric RVGE cases cause disruption to families and parental stress.
On June 21st the NSA provided congressional intelligence committees with what it said were over 50 cases in which the programmes disclosed by Mr Snowden had contributed to the "understanding and, in many cases, disruption" of terrorist plots in America and over 20 other countries.
The discrepancy between these two studies appears to be significant, but it should be emphasized that in both cases disruption of Mbd3 function did not affect cell proliferation and only affected some differentiation potential.
In simple cases disruption occurs when the remedy is close but not correct and when the patient is sensitive to the remedy.
In some cases disruption in the early stages of lineage commitment leads to a total lack of cell subsets further downstream, as is the case in severe combined immunodeficiency (SCID).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com