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Where possible, we have numbered the base case (comparator) for the analysis as (0). 5 CEA = Cost Effectiveness Analysis.
For this hypothetical alternative scenario with importation on December 1, 2009, the cumulative incidence reaches one paralytic case 7 days later than for the reference case with November 1 WPV introduction, and thus we also move all oSIA rounds by 7 days for the hypothetical alternative case comparator, which we use to further explore the impact of different pSIA scenarios.
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A description of each of the simulated scenarios and relevant base case comparators is provided in Table 6.
For each case one comparator control postcode was randomly selected from within the service area of the laboratory to which the case stool sample was sent.
In this case, the comparator is a mix of several exposures, which may affect the conclusion about the effect of certain insulins (analogues).
Based on WHO recommendations, an intervention may be considered cost effective if the cost per QALY is less than the country's GDP per capita [ 35, 40] C1 is the cost of the new intervention, and E1 is the effect of the new intervention, whereas C0 and E0 are the cost and effect of the base case or comparator.
Clearly identifying the type of 'case' and the unit of analysis, and considering the need for multiple cases and comparators.
Table 2 below describes two options for estimating sample size based on case/comparators ratio: 1 case/ 1 comparator and 1 case/ 4 comparators.
58 Eight cases were reported in liraglutide-treated patients compared with one case in active comparators, corresponding to an incidence of 1.6 versus 0.7 events per 1,000 subject-years (P<0.94).
In case no common comparator is available an unadjusted indirect comparison remains as an option.
We have collected and stored blood samples from both the case and the comparator groups in the study.
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CEO of Professional Science Editing for Scientists @ prosciediting.com