Uncertainties are cascaded sequentially through model components starting with "upstream" drivers (e.g., mitigation options, emissions, carbon cycle response, and global climate sensitivity) and then "downstream" to local climate change, exposures, and health impacts.
A MAPK signalling cascade is sequentially activated by three protein kinases, a MAP kinase kinase Kinase (MAPKKK or MEKK), a MAP kinase kinase (MAPKK or MKK) and a MAP kinase (MPK).
Loss- and gain-of-function experiments suggest that dpn activity is critical for the proper regulation of cell proliferation in the larval brain [ 63]. cas is involved in a cascade of sequentially expressed transcription factors, which translates information on timing of GMC formation [ 64].
However, as primary gene responses give way to secondary responses, gene expression cascades are sequentially propagated across time.
Basically I had one day a week -- maybe two -- when I felt human". What ensued over the following years was a cascade of medications sequentially and in combinations, none of which succeeded in knocking the virus down to undetectable levels.
There are three groups of enzymes in the MAPK signalling cascade that are sequentially activated: MAP kinase kinase kinase (MKKK, MEKK or MAP3K), MAP kinase kinase (MKK, MEK, or MAP2K) and MAP kinase (MAPK).
As with other MAPKs, ERK represents a three-tiered kinase cascade composed of the sequentially-acting kinases.
Zhou, J. et al. A sequentially priming phosphorylation cascade activates the gliomagenic transcription factor Olig2. Cell Rep. 18, 3167 3177 (2017).
Each MAPK cascade is composed of three sequentially activating kinases.
