Sentence examples for cascade of alterations from inspiring English sources

The bacterial stress response can be defined as a cascade of alterations in gene expression and protein activity to allow survival under potentially damaging conditions sensed by bacteria.

Any measurable increase in overall thermal strain leads to a cascade of alterations in match characteristics, neuromuscular function, oxidative stress and antioxidant status, which can impact on performance acutely and potentially more so in successive matches during tournament play.

Conversely, the relocation of one paralog to a novel genomic locale has the potential to initiate a cascade of alterations to its ancestral regulatory repertoire and genic neighborhood, thereby increasing its probability of embarking on a divergent evolutionary trajectory [ 24].

We found that mutually exclusive mutations of NRAS and BRAF genes occur at quite same rate in cultured and uncultured melanomas (either primary or metastatic lesions), confirming that they represent an early event within the cascade of alterations involved into the melanomagenesis.

In turn, miR-10b inhibits HOXD10 and, through a cascade of cellular alterations, inhibits the expression of the prometastatic gene RHOC [ 320, 321].

Expression of miR-10b was found to be induced by the transcription factor Twist; in turn, miR-10b inhibits the translation of the transcription factor homeobox D10 (HOXD10), resulting in a cascade of cellular alterations that include expression of the prometastatic gene RHOC (ras homologue gene family member C), a gene that promotes cancer cell migration and invasion.

The bronchial multistep carcinogenesis is a cascade of molecular genetic alterations responsible for the histological continuum from squamous metaplasia to invasive bronchial carcinoma.

It has been well established that, following axon transection, the distal axon segment undergoes a cascade of stereotypical degenerative alterations, termed Wallerian degeneration.

A prolonged continuation of the biological and behavioral responses following acute traumatic stress may lead to greater pairing of the traumatic memory with distress, initiating a cascade of secondary biological alterations with long-term adverse consequences including interference with fear extinction learning and retention [ 33- 36].

Trauma and hemorrhage trigger a complex cascade of events associated with alterations in hemodynamic, metabolic, and inflammatory/immune responses that are largely orchestrated by cytokines and chemokines, among a host of factors [5] [7].

In sepsis, a cascade of macrocirculatory and microcirculatory alterations may induce an inability to maintain vasoconstriction, and can lead to severe hypotension [ 3].