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Researchers report that obese mice carry altered communities of intestinal bugs, which produce DNA-damaging acid that leave the mice more susceptible to liver cancer.
We therefore expected that only merlin isoform 2 (merlin-iso2) knockout mice, associated with axon-intrinsic pathology (Schulz et al., 2013), would carry altered NRG1 type III.
Over 80% of ARMS patients carry altered ALK gene copy number [273], identifying ALK as a potential therapeutic target in ARMS patients.
The essence of the model (an arms race between cells and viruses) is very elegant, and invokes known processes (there are several cases where viruses are known to carry altered genomes – phage genomes with uracil instead of thymine, for example).
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Our approach relies on sensitized phenotypic screening of megabase-sized chromosomal deletion and deficiency lines carrying altered copy numbers of ∼30 linked genes.
Studies on mice carrying altered Ctbp genes suggest that two mutant genes (Ctbp1 and Ctbp2) play unique regulatory roles during development (Chinnadurai 2003).
To test this, a series of mutant U1 snRNAs, U1 sm1 to U1 sm5, carrying altered Sm-binding motifs were transiently expressed in HeLa cells (Fig 3A).
Identification of segments carrying altered numbers of copies was achieved with the Patchwork R package (Mayrhofer et al., 2013), which quantifies the log-relative change in DNA content for each chromosomal region.
By using fluorescein-isothiocyanate (FITC -conjugated peanut agglutinin (PNA) and sodium dodecyl sulFITC -conjugatedide gel electropeanutis (SDS-Pagglutininve investigated glycoPNAteins candying altered carbohydrate epitopesodiumormal andodecylnomatous human colorectal mucosa.
In summary, we concluded that processing of mutant yeast 18S rRNAs carrying altered rm1 or rm2 elements can be restored by re-establishing the base-pairing capacity of the m1 and m2 motifs of snR30.
As apoptosis and autophagy are highly interconnected [ 26] and because the ability of DHA to induce apoptosis is related to its ability to stimulate autophagic activation in tumor cells with wild-type p53 [ 22], we investigated whether autophagy may also be stimulated by DHA in cell models carrying altered p53.
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