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If a F1 embryo carries mutation, it should be heterozygous, and theoretically approximate 50% colonies will harbor mutations.
Consistent with this result, we also showed that induction of CDKN1A expression in MDA-MB-231 cell line, which carries mutation in p53.
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The latter is an early-flowering cultivar and carries mutations in Ghd7 and PRR37 (Kim et al. [2013]).
A large fraction of human tumours carries mutations in the p53 gene.
Jews are more likely to carry mutations for Tay-Sachs, Africans for sickle cell anemia.
Though iPS cells hold great promise, they carry mutations and other abnormalities that might rule them out for medical therapies.
We see this variability in outcome as well among women who have a powerful inherited susceptibility to breast cancer, carrying mutations in their BRCA genes.
Women who carry mutations in genes called BRCA are already known to have a substantially higher risk of breast cancer, at around 65%.
Most of the mutants carried mutations in marR.
Three mutants (CH1, CH2, and CH7) carried mutations in acrR.
Families with highly penetrant retinoblastomas often carry mutations that result in early stop codons.
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